Amifostine API – Uses, Mechanism, Suppliers & Pharmaceutical Guide (2026)

 

Introduction to Amifostine API

Amifostine is a cytoprotective agent widely used in oncology to protect normal tissues from the harmful effects of chemotherapy and radiation therapy. It is especially valuable in reducing treatment-related toxicity in cancer patients.

As a specialized pharmaceutical ingredient, Amifostine API is used by manufacturers to develop supportive care medications in cancer treatment.

Amifostine-API-Uses-Mechanism-Suppliers-&-Pharmaceutical-Guide-(2026)

At Swapnroop Drugs & Pharmaceuticals, we provide reliable sourcing solutions for Amifostine API, ensuring high-quality material and compliance with international pharmaceutical standards.

Basic Product Information

• Product Name: Amifostine
• CAS Number: 20537-88-6
• Molecular Formula: C5H15N2O3PS
• Molecular Weight: 214.24 g/mol
• Category: Cytoprotective Agent / Oncology API
• Dosage Form: Injectable
• Grades Available: IP / BP / USP / EP

Mechanism of Action

Amifostine works as a prodrug that is converted in the body to its active metabolite. This active form helps protect healthy cells by:

• Scavenging free radicals
• Reducing DNA damage caused by radiation and chemotherapy
• Selectively protecting normal tissues without reducing the effectiveness of cancer treatment

This selective protection makes it highly useful in oncology therapies.

Medical Uses of Amifostine

Protection During Chemotherapy

Amifostine is used to:

• Reduce kidney toxicity caused by certain chemotherapy drugs
• Minimize side effects of cancer treatment

Radiation Therapy Support

• Protects salivary glands during radiation therapy
• Helps reduce complications such as dry mouth

Supportive Oncology Care

It is often included in treatment plans to improve patient tolerance to aggressive therapies.

Manufacturing Overview

The production of Amifostine API involves:

1. Controlled chemical synthesis
2. Purification and stabilization
3. Quality testing as per pharmacopeial standards
4. Packaging suitable for pharmaceutical use

At Swapnroop Drugs & Pharmaceuticals, we ensure sourcing from GMP-compliant manufacturers to maintain high levels of safety and quality.

Quality Considerations

When sourcing Amifostine API, pharmaceutical companies should consider:

• High purity and stability
• Compliance with IP, BP, USP, or EP standards
• Availability of COA, MSDS, and regulatory documentation
• Consistent supply for manufacturing needs

Reliable sourcing ensures effectiveness and safety in oncology formulations.

Market Demand and Industry Trends

The demand for Amifostine is driven by:

• Increasing cancer treatment procedures
• Growing use of supportive care drugs in oncology
• Focus on reducing treatment-related side effects

India continues to be an important supplier of oncology APIs due to its manufacturing capabilities and regulatory expertise.

Storage and Handling

• Store in a cool and dry environment
• Protect from light and moisture
• Use airtight containers
• Follow proper pharmaceutical handling procedures

Regulatory Compliance

Amifostine API must meet:

• Good Manufacturing Practices (GMP)
• Pharmacopeial standards (IP, BP, USP, EP)
• International regulatory requirements for export

About Swapnroop Drugs & Pharmaceuticals

Swapnroop Drugs & Pharmaceuticals is a trusted partner for pharmaceutical companies seeking reliable API sourcing. We focus on:

• Bulk API supply
• Consistent quality assurance
• Timely delivery and logistics
• Complete documentation support

We help businesses connect with dependable Amifostine API manufacturers and ensure smooth procurement.

Frequently Asked Questions (FAQs)

1. What is Amifostine used for?

Amifostine is used to protect healthy tissues from the side effects of chemotherapy and radiation therapy.

2. What is the CAS number of Amifostine?

The CAS number is 20537-88-6.

3. How does Amifostine work?

It acts as a cytoprotective agent by reducing damage to normal cells during cancer treatment.

4. Where can I source Amifostine API?

You can source it from reliable suppliers like Swapnroop Drugs & Pharmaceuticals with proper quality documentation.

5. Is Amifostine used in cancer treatment?

Yes, it is used as a supportive drug to reduce side effects of chemotherapy and radiation.

6. How is Amifostine API supplied?

It is supplied in bulk packaging suitable for injectable pharmaceutical formulations.

7. What should buyers check before sourcing?

Buyers should verify purity, certifications, and supplier reliability.

Conclusion

Amifostine API plays an important role in modern oncology by protecting healthy tissues and improving patient tolerance to cancer treatments. Its use in supportive care makes it a valuable component in pharmaceutical manufacturing.

With a commitment to quality and reliability, Swapnroop Drugs & Pharmaceuticals provides trusted sourcing solutions for Amifostine API, supporting pharmaceutical companies worldwide.