Amlodipine Besylate API (CAS 111470-99-6): Uses, Manufacturers, Suppliers & Global Market Trends

Introduction to Amlodipine Besylate

What is Amlodipine Besylate?

When discussing essential cardiovascular medications, Amlodipine Besylate (CAS 111470-99-6) is one of the most widely recognized and prescribed APIs globally. It plays a critical role in managing hypertension (high blood pressure) and angina (chest pain), making it a cornerstone drug in modern cardiovascular therapy.

Amlodipine-Besylate-API-CAS 111470-99-6-Uses-Manufacturers-Suppliers-Global-Market-Trend

Amlodipine belongs to the calcium channel blocker (CCB) class, specifically the dihydropyridine group. It works by relaxing blood vessels, allowing blood to flow more easily and reducing the workload on the heart. This mechanism makes it highly effective and well-tolerated by patients across different age groups. 

From a business perspective, the demand for Amlodipine Besylate API manufacturers and suppliers is consistently high. With cardiovascular diseases being one of the leading causes of death worldwide, the need for reliable and high-quality APIs like Amlodipine continues to grow steadily.

Chemical Identification & CAS Details

Amlodipine Besylate is identified by CAS No: 111470-99-6, ensuring global recognition and traceability across pharmaceutical supply chains. It is the besylate salt form of amlodipine, which enhances its stability and bioavailability.

Chemically, it belongs to the dihydropyridine derivative class, known for its vascular selectivity. This means it primarily acts on blood vessels rather than directly affecting the heart muscle, reducing the risk of adverse cardiac effects.

For manufacturers, ensuring high purity, controlled crystallization, and consistent quality is crucial. Regulatory authorities require strict compliance with documentation such as COA, MSDS, and impurity profiles to ensure safety and efficacy.

Mechanism of Action

Calcium Channel Blocking Activity

Amlodipine works by inhibiting L-type calcium channels in vascular smooth muscle cells. Calcium ions play a key role in muscle contraction, including the contraction of blood vessels.

By blocking calcium entry, Amlodipine causes vasodilation, which lowers blood pressure and improves blood flow. This mechanism helps reduce the risk of complications such as stroke and heart attack.

Clinical Importance in Cardiovascular Treatment

Clinically, Amlodipine is widely used as a first-line treatment for hypertension. It is also effective in managing chronic stable angina and vasospastic angina.

One of its major advantages is its long duration of action, allowing once-daily dosing. This improves patient compliance and makes it a preferred choice among healthcare providers.

Key Applications

Treatment of Hypertension

Amlodipine is primarily used to treat high blood pressure, helping reduce the risk of cardiovascular events such as stroke, heart attack, and kidney disease.

Use in Angina Management

It is also used to manage angina, improving oxygen supply to the heart and reducing chest pain episodes. This makes it essential in long-term cardiovascular care.

Dosage Forms & Strengths

Tablet Variants

Amlodipine Besylate is commonly available in:

• 2.5 mg tablets
• 5 mg tablets
• 10 mg tablets

These strengths allow flexible dosing based on patient needs.

Market Demand by Dosage

The 5 mg and 10 mg variants dominate the market due to their widespread use in hypertension management. Lower doses are often used for elderly patients or initial therapy.

Global Market Overview

Market Growth & Trends

The global Amlodipine Besylate API market is driven by the increasing prevalence of cardiovascular diseases. With aging populations and lifestyle-related health issues on the rise, demand for antihypertensive drugs continues to grow.

Regional Demand Insights

Region	Market Share
Asia-Pacific	~ 45%
North America	~25%
Europe	~20%
Others	~10%

Asia-Pacific leads due to large patient populations and cost-effective manufacturing capabilities.

Manufacturing Process Overview

API Production Stages

The production of Amlodipine Besylate involves chemical synthesis, salt formation, purification, and crystallization. Each step requires strict control to ensure product quality.

Quality Control Measures

Quality testing includes:

• Purity analysis
• Stability testing
• Impurity profiling

Compliance with international standards is essential for global distribution.

Regulatory Compliance

GMP & International Standards

Manufacturers must adhere to GMP, WHO, US FDA, and EU guidelines to ensure product safety and export eligibility.

Benefits of Amlodipine API

Amlodipine offers several advantages, including high efficacy, long duration of action, good patient tolerance, and strong global demand. Its widespread use makes it a reliable API in the pharmaceutical industry.

Challenges in Market

Challenges include intense competition from generic manufacturers, pricing pressure, and regulatory requirements. Companies must focus on quality and cost efficiency to remain competitive.

Demand Drivers

The rising prevalence of hypertension, aging populations, and increasing awareness of cardiovascular health are key drivers of demand for Amlodipine Besylate.

Choosing a Reliable Supplier

Selecting a supplier involves evaluating regulatory certifications, product quality, supply consistency, and pricing. A reliable partner ensures long-term success in the pharmaceutical business.

Company Overview – Swapnroop Drugs & Pharmaceuticals

At Swapnroop Drugs and Pharmaceuticals, we take pride in being a trusted global supplier of pharmaceutical raw materials — delivering excellence, reliability, and regulatory compliance since 2013.

We specialize in supplying high-quality APIs with complete documentation, competitive pricing, and consistent supply. Our commitment to quality and customer satisfaction makes us a preferred partner for pharmaceutical companies worldwide.

Conclusion

AmlodipineBesylate (CAS 111470-99-6) is a cornerstone API in cardiovascular treatment. Its effectiveness, safety profile, and widespread use ensure strong and consistent global demand.

For manufacturers and suppliers, this API presents significant opportunities driven by growing healthcare needs and expanding pharmaceutical markets. Maintaining high quality and regulatory compliance is essential for success in this competitive industry.

FAQs

1. What is Amlodipine Besylate used for?

It is used to treat hypertension and angina by relaxing blood vessels and improving blood flow.

2. What is the CAS number of Amlodipine Besylate?

The CAS number is 111470-99-6.

3. What are the common strengths available?

It is available in 2.5 mg, 5 mg, and 10 mg tablets.

4. Why is Amlodipine widely used?

Due to its effectiveness, long-lasting action, and good patient tolerance.

5. Who are reliable Amlodipine API suppliers?

Certified pharmaceutical companies like Swapnroop Drugs and Pharmaceuticals.

6. Why choose Swapnroop Drugs and Pharmaceuticals?

At Swapnroop Drugs and Pharmaceuticals, we take pride in being a trusted global supplier of pharmaceutical raw materials — delivering excellence, reliability, and regulatory compliance since 2013.