Amlodipine Mesylate (CAS 88150-42-9) – Complete Pharmaceutical Guide

Introduction to Amlodipine Mesylate

What is Amlodipine Mesylate?

If you’re involved in the pharmaceutical industry or even just curious about cardiovascular medicines, Amlodipine Mesylate (CAS 88150-42-9) is a name you’ll come across quite often. It is a salt form of amlodipine, a well-known calcium channel blocker used for treating hypertension and angina. But here’s the interesting part—different salt forms exist to optimize performance, and mesylate is one of the promising alternatives gaining attention.

Amlodipine-Mesylate-CAS-88150-42-9-Complete-Pharmaceutical-Guide

Amlodipine Mesylate works by relaxing blood vessels, allowing blood to flow more freely. This helps lower blood pressure and reduces the workload on the heart. Its long-acting nature ensures stable blood pressure control over 24 hours, making it highly effective for daily dosing.

What makes this compound important for manufacturers is its balance between stability, solubility, and cost-efficiency. As pharmaceutical companies look for reliable and optimized API options, Amlodipine Mesylate is emerging as a strong candidate in global markets.

CAS Number and Chemical Identity

The CAS Number 88150-42-9 is associated with the core amlodipine molecule, ensuring consistency across different salt forms, including mesylate. This unique identifier plays a crucial role in regulatory documentation, global trade, and quality assurance.

Amlodipine Mesylate is formed by combining amlodipine with methanesulfonic acid, resulting in a stable salt. This chemical modification enhances its pharmaceutical properties, making it suitable for large-scale manufacturing and formulation.

Chemical and Physical Properties

Molecular Structure and Formula

The molecular structure of Amlodipine Mesylate is designed for targeted therapeutic action. It interacts specifically with calcium channels in vascular smooth muscles, ensuring effective blood pressure control.

From a manufacturing perspective, the structure provides excellent chemical stability. This stability ensures that the API maintains its potency during storage, transportation, and formulation processes. That’s a huge advantage when producing medicines at scale.

Physical Characteristics and Solubility

Amlodipine Mesylate appears as a white to off-white crystalline powder, which is ideal for pharmaceutical processing. Its solubility profile supports efficient absorption in the body, ensuring the drug delivers consistent therapeutic results.

This combination of physical stability and solubility makes it a preferred option for many pharmaceutical formulations, especially in tablet manufacturing.

Mechanism of Action

Role in Calcium Channel Blocking

Think of calcium channels as gateways that control muscle contraction in blood vessels. When calcium enters these channels, the vessels tighten, increasing blood pressure. Amlodipine Mesylate blocks these channels, preventing calcium entry and allowing the vessels to relax.

This targeted action ensures effective blood pressure reduction without significantly affecting other bodily functions, making it a safe and reliable treatment option.

Impact on Blood Pressure Regulation

By reducing vascular resistance, Amlodipine Mesylate helps maintain a steady and controlled blood pressure level. Unlike short-acting drugs, it provides a gradual and sustained effect, reducing the risk of sudden blood pressure drops.

Patients benefit from improved circulation, reduced cardiac stress, and lower risks of heart-related complications.

Medical Uses and Applications

Treatment of Hypertension

Amlodipine Mesylate is widely used for treating hypertension, one of the most common chronic conditions worldwide. Its effectiveness and long duration of action make it a preferred choice for physicians.

It is often included in combination therapies, enhancing its effectiveness in managing complex cases of high blood pressure.

Angina and Cardiovascular Benefits

In addition to hypertension, Amlodipine Mesylate is used for treating angina. By improving blood flow to the heart, it helps reduce chest pain and improves overall heart function.

Its dual action makes it a valuable API in cardiovascular drug formulations.

Market Demand and Industry Trends

Global Demand for Amlodipine API

The global demand for Amlodipine APIs, including mesylate, continues to rise due to increasing cardiovascular disease prevalence. Pharmaceutical companies are constantly seeking high-quality, cost-effective API sources.

Growth in Emerging Markets

Emerging markets are driving demand significantly. Increased healthcare access, awareness, and government initiatives are boosting the use of antihypertensive medications, including Amlodipine Mesylate.

Manufacturing Process Overview

Raw Materials and Synthesis

The synthesis of Amlodipine Mesylate involves controlled chemical reactions using high-purity raw materials. The process is optimized to ensure consistent quality and yield.

Quality Control and Compliance

Strict quality control measures are implemented during manufacturing. Techniques like HPLC and IR spectroscopy are used to verify purity and compliance with pharmacopoeial standards.

Regulatory Standards and Certifications

IP, BP, USP Standards

Amlodipine Mesylate must meet international standards such as IP, BP, and USP, ensuring global acceptance and quality assurance.

WHO-GMP and FDA Compliance

Manufacturers must comply with WHO-GMP guidelines and relevant FDA regulations to ensure product safety and export eligibility.

Packaging, Storage, and Stability

Storage Conditions

The API should be stored in a cool, dry, and well-ventilated environment, away from direct sunlight and moisture.

Shelf Life and Handling

With proper storage, Amlodipine Mesylate maintains a long shelf life. Careful handling ensures its stability throughout its lifecycle.

Comparison with Other Amlodipine Salts

Feature	Mesylate	Besylate	Maleate
Stability	High	Very High	High
Solubility	Good	Excellent	Moderate
Cost	Competitive	Higher	Moderate
Usage	Growing	Widely Used	Emerging

Advantages of Mesylate Form

Amlodipine Mesylate offers a balanced combination of cost, stability, and solubility, making it an attractive choice for manufacturers looking for optimized formulations.

Supplier Selection Guide

Key Factors to Consider

Selecting the right supplier is crucial. You should evaluate compliance, quality consistency, pricing, and documentation transparency before making a decision.

Importance of Reliable Manufacturers

A reliable manufacturer ensures uninterrupted supply, consistent quality, and regulatory compliance, which are essential for successful pharmaceutical production.

About Swapnroop Drugs and Pharmaceuticals

Company Overview

At Swapnroop Drugs and Pharmaceuticals, we take pride in being a trusted global supplier of pharmaceutical raw materials, delivering excellence, reliability, and regulatory compliance since 2013. Our focus on quality and customer satisfaction sets us apart in the industry.

Global Supply and Expertise

We specialize in supplying high-quality APIs, including Amlodipine Mesylate, to clients worldwide. Our expertise, timely delivery, and competitive pricing make us a preferred partner for pharmaceutical companies.

Conclusion

AmlodipineMesylate (CAS 88150-42-9) is an emerging and valuable API in the pharmaceutical industry. Its effectiveness in treating hypertension and angina, combined with its stability and cost-efficiency, makes it a strong alternative to other salt forms. As global demand continues to rise, choosing the right supplier becomes increasingly important for ensuring consistent quality and performance.

FAQs

1. What is Amlodipine Mesylate used for?

It is used to treat hypertension and angina by relaxing blood vessels and improving blood flow.

2. What is the CAS number of Amlodipine Mesylate?

The CAS number associated with the amlodipine molecule is 88150-42-9.

3. How is Amlodipine Mesylate different from Besylate?

Mesylate offers a cost-effective alternative with good solubility, while Besylate is more widely used with slightly higher stability.

4. What are the storage conditions for Amlodipine Mesylate?

It should be stored in a cool, dry place away from moisture and direct sunlight.

5. Why choose Swapnroop Drugs and Pharmaceuticals for APIs?

Swapnroop Drugs and Pharmaceuticals provides high-quality APIs with global supply capabilities, regulatory compliance, and trusted industry experience since 2013.